The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of
laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and …

MAS-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX,
are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A …

Thermosensors expressed in peripheral somatosensory neurons sense a wide range of
environmental temperatures. While thermosensors detecting cool, warm and hot …

Rationale: Gastroesophageal reflux disease (GERD) is commonly associated with atopic
disorders, but cause–effect relationships remain unclear. Objectives: We applied Mendelian …

The heart is a functional syncytium controlled by a delicate and sophisticated balance
ensured by the tight coordination of its several cell subpopulations. Accordingly …

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal
or avoidance of tissue damage. While pain arises from both the skin and viscera, we …

Many internal organs change volume periodically. For example, the stomach accommodates
ingested food and drink, the bladder stores urine, the heart fills with blood, and the lungs …

Airway sensory nerves detect a wide variety of chemical and mechanical stimuli, and relay
signals to circuits within the brainstem that regulate breathing, cough, and …