Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

Highlights•The cytochrome P450 4 (CYP4) family of enzymes is responsible for the
activation or deactivation of numerous endogenous substrates.•CYP4 is a vital therapeutic …

Oxylipins, the oxidation products of polyunsaturated fatty acids, are important signaling
molecules in living organisms. Some of them have pro-inflammatory properties, while others …

Metabolic syndrome (MetS) is a complex condition encompassing a constellation of
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …

Patients with myocardial ischemic diseases or who are undergoing one of various heart
treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous …

Arachidonic acid (AA) is a polyunsaturated fatty acid with a structure of 20: 4 (ω-6).
Cytochrome P450s (CYPs) metabolize AA to several regioisomers and enantiomers of …

Fatty acid omega hydroxylase P450s consist of enzymes that hydroxylate various chain-
length saturated and unsaturated fatty acids (FAs) and bioactive eicosanoid lipids. The …

Introduction: Oxylipins are mediators of oxidative stress. To characterize the underlying
inflammatory processes and phenotype effect of iron metabolism disorders, we investigated …

Introduction: Oxylipins are mediators of oxidative stress. To characterize the underlying
inflammatory processes and phenotype the effect of iron metabolism disorders, we …

Abstract Background Metabolic syndrome (MetS) is a complex condition encompassing a
constellation of cardiometabolic abnormalities. Integratively phenotyping the molecular …