Monoclonal antibody therapies against SARS-CoV-2

D Focosi, S McConnell, A Casadevall… - The Lancet Infectious …, 2022 - thelancet.com
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …

The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies

D Focosi, S McConnell, A Casadevall - Drug Resistance Updates, 2022 - Elsevier
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …

Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants

M Bhattacharya, S Chatterjee, SS Lee, K Dhama… - Drug Resistance …, 2023 - Elsevier
Since the origin of the wild strain of SARS-CoV-2, several variants have emerged, which
were designated as VOC, VOI, and VUM from time to time. The Omicron variant is noted as …

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants

KM Ali, PMA Rashid, AM Ali, AM Tofiq… - European Journal of …, 2023 - Wiley Online Library
Background The pandemic of coronavirus disease 2019 (COVID‐19) has a broad spectrum
of clinical manifestations. The severe acute respiratory syndrome coronavirus‐2 (SARS …

Rise and fall of SARS-CoV-2 variants in Rotterdam: Comparison of wastewater and clinical surveillance

RW Izquierdo-Lara, L Heijnen, BBO Munnink… - Science of the Total …, 2023 - Elsevier
Monitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological
surveillance, correlating not only viral RNA levels with the infection dynamics within the …

[HTML][HTML] Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics

RA Rojas Chávez, M Fili, C Han… - PLOS Computational …, 2024 - journals.plos.org
New sublineages of SARS-CoV-2 variants-of-concern (VOCs) continuously emerge with
mutations in the spike glycoprotein. In most cases, the sublineage-defining mutations vary …

[HTML][HTML] Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus from November 2020 to October 2021: The Passage of Waves of Alpha and Delta Variants of …

AC Chrysostomou, B Vrancken, C Haralambous… - Viruses, 2022 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019 resulted in the coronavirus disease 2019 (COVID-19) pandemic, which has …

[HTML][HTML] Genomic surveillance of genes encoding the SARS-CoV-2 spike protein to monitor for emerging variants on Jeju Island, Republic of Korea

YR Ha, HJ Kim, JS Park, YS Chung - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
has been fueled by new variants emerging from circulating strains. Here, we report results …

Genomic epidemiology of the main SARS‐CoV‐2 variants in Italy between summer 2020 and winter 2021

A Bergna, A Lai, CD Ventura… - Journal of Medical …, 2023 - Wiley Online Library
Since the beginning of the pandemic, SARS‐CoV‐2 has shown a great genomic variability,
resulting in the continuous emergence of new variants that has made their global monitoring …

[HTML][HTML] Characterization of SARS-CoV-2 genetic evolution in vaccinated and non-vaccinated patients from the Kenyan population

S Oyola - Research Square, 2023 - ncbi.nlm.nih.gov
Vaccination is a key control measure of COVID-19 by preventing severe effects of disease
outcomes, reducing hospitalization rates and death, and increasing herd immunity …