Artemisinins: pharmacological actions beyond anti-malarial

WE Ho, HY Peh, TK Chan, WSF Wong - Pharmacology & therapeutics, 2014 - Elsevier
Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis—a meta-analysis of comparative and non-comparative clinical trials

J Zwang, PL Olliaro - PLoS neglected tropical diseases, 2014 - journals.plos.org
Background Extensive use of praziquantel for treatment and control of schistosomiasis
requires a comprehensive understanding of efficacy and safety of various doses for different …

Schistosomiasis in African infants and preschool children: let them now be treated!

JR Stothard, JC Sousa-Figueiredo, M Betson… - Trends in …, 2013 - cell.com
The occurrence of schistosomiasis within African infants and preschool children has been
much better documented in recent years, revealing an important burden of disease …

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

R Liu, HF Dong, Y Guo, QP Zhao, MS Jiang - Parasites & vectors, 2011 - Springer
Background Praziquantel has been used as first-line drug for chemotherapy of
schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also …

Efficacy and safety of praziquantel 40 mg/kg in preschool-aged and school-aged children: a meta-analysis

J Zwang, P Olliaro - Parasites & vectors, 2017 - Springer
Background Children carry most of the schistosomiasis burden. While school-aged children
are the principal target group of preventive chemotherapy with praziquantel, limited …

Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis

L Perez del Villar, FJ Burguillo, J Lopez-Aban, A Muro - 2012 - journals.plos.org
Background Chemotherapy based on repeated doses of praziquantel is still the most
effective control strategy against Schistosomiasis, however artemisinin derivatives emerged …

A wake up call for urinary schistosomiasis: reconciling research effort with public health importance

D Rollinson - Parasitology, 2009 - cambridge.org
This review considers the current status of urinary schistosomiasis, caused by infection with
Schistosoma haematobium, and argues that greater research effort and focus are needed to …

New clinical application prospects of artemisinin and its derivatives: a scoping review

Y Huang, Y Yang, G Liu, M Xu - Infectious Diseases of Poverty, 2023 - Springer
Background Recent research has suggested that artemisinin and its derivatives may have
therapeutic effects on parasites, viruses, tumors, inflammation and skin diseases. This study …

Drugs for treating Schistosoma mansoni infection

A Danso‐Appiah, PL Olliaro… - Cochrane Database …, 2013 - cochranelibrary.com
Background Schistosoma mansoni is a parasitic infection common in the tropics and sub‐
tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the …

Drug repurposing for schistosomiasis: combinations of drugs or biomolecules

MJ Gouveia, PJ Brindley, F Gärtner, JMC Costa… - Pharmaceuticals, 2018 - mdpi.com
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …