Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical
role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure …

In today's pharmaceutical research and development, physiologically-based
pharmacokinetic (PBPK) modeling plays an important role in the design, evaluation and …

Cytochrome P450 (P450) and uridine 5′-diphospho-glucuronosyltransferase (UGT)
enzymes mediate a major proportion of phase I and phase II metabolism of xenobiotics. In …

Ethoxy-2, 3-difluoro-4-(trans-4-propylcyclohexyl) benzene (EDPrB) is a typical fluorinated
liquid-crystal monomer (LCM). LCMs contaminants are becoming increasingly concerning …

Pharmacotherapy in pediatric patients is challenging in view of the maturation of organ
systems and processes that affect pharmacokinetics and pharmacodynamics. Especially for …

Over the past two decades, the pig has gained attention as a potential model for human drug
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death
worldwide. New animal models that faithfully recapitulate human HCC phenotypes are …

Human hepatic membrane-embedded transporter proteins are involved in trafficking
endogenous and exogenous substrates. Even though impact of transporters on …

In vitro to in vivo extrapolation (IVIVE) enables prediction of in vivo clinical outcomes related
to drug exposure in various populations from in vitro data. Prudent IVIVE requires scalars …

Pediatric drug research is still substandard, not reaching the same quality level as adult drug
research. Despite the efforts made by the Food and Drug Administration and European …