Modularity in biological networks

SA Alcalá-Corona, S Sandoval-Motta… - Frontiers in …, 2021 - frontiersin.org
Network modeling, from the ecological to the molecular scale has become an essential tool
for studying the structure, dynamics and complex behavior of living systems. Graph …

Pseudogenes in cancer: state of the art

AK Nakamura-García, J Espinal-Enríquez - Cancers, 2023 - mdpi.com
Simple Summary Out of the billions of nucleotides comprising the human DNA, a substantial
proportion (98%) represents non-coding DNA, meaning DNA that is not translated into …

Coordinated inflammation and immune response transcriptional regulation in breast cancer molecular subtypes

TE Velazquez-Caldelas, JM Zamora-Fuentes… - Frontiers in …, 2024 - frontiersin.org
Breast cancer, characterized by its complexity and diversity, presents significant challenges
in understanding its underlying biology. In this study, we employed gene co-expression …

Methylation-related genes involved in renal carcinoma progression

JM Zamora-Fuentes, E Hernández-Lemus… - Frontiers in …, 2023 - frontiersin.org
Renal carcinomas are a group of malignant tumors often originating in the cells lining the
small tubes in the kidney responsible for filtering waste from the blood and urine production …

Loss of long distance co-expression in lung cancer

SD Andonegui-Elguera, JM Zamora-Fuentes… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is one of the deadliest, most aggressive cancers. Abrupt changes in gene
expression represent an important challenge to understand and fight the disease. Gene co …

k-core genes underpin structural features of breast cancer

R Dorantes-Gilardi, D García-Cortés… - Scientific Reports, 2021 - nature.com
Gene co-expression networks (GCNs) have been developed as relevant analytical tools for
the study of the gene expression patterns behind complex phenotypes. Determining the …

Gene expression and co-expression networks are strongly altered through stages in clear cell renal carcinoma

JM Zamora-Fuentes, E Hernández-Lemus… - Frontiers in …, 2020 - frontiersin.org
Clear cell renal carcinoma (ccRC) is a highly heterogeneous and progressively malignant
disease. Analyzing ccRC progression in terms of modifications at the molecular and genetic …

Luminal a breast cancer co-expression network: Structural and functional alterations

D García-Cortés, E Hernández-Lemus… - Frontiers in …, 2021 - frontiersin.org
Luminal A is the most common breast cancer molecular subtype in women worldwide.
These tumors have characteristic yet heterogeneous alterations at the genomic and …

Functional impact of multi-omic interactions in breast cancer subtypes

S Ochoa, E Hernández-Lemus - Frontiers in Genetics, 2023 - frontiersin.org
Multi-omic approaches are expected to deliver a broader molecular view of cancer.
However, the promised mechanistic explanations have not quite settled yet. Here, we …

The role of copy number variants in gene co-expression patterns for luminal b breast tumors

C Hernández-Gómez, E Hernández-Lemus… - Frontiers in …, 2022 - frontiersin.org
Gene co-expression networks have become a usual approach to integrate the vast amounts
of information coming from gene expression studies in cancer cohorts. The reprogramming …