Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Background Quercetin is a natural flavonoid, which widely exists in nature, such as tea,
coffee, apples, and onions. Numerous studies have showed that quercetin has multiple …

Destruction of habitat is the major cause for loss of biodiversity including variation in life
history and habitat ecology. Each species and population adapts to its environment …

The main objective of this review is to examine the role of endogenous reactive
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

Insulin signaling in central nervous system (CNS) has emerged as a novel field of research
since decreased brain insulin levels and/or signaling were associated to impaired learning …

Background Eukaryotic cells have evolved various response mechanisms to counteract the
deleterious consequences of oxidative stress. Among these processes, metabolic alterations …

Oxidative stress is generally considered as the consequence of an imbalance between pro-
and antioxidants species, which often results into indiscriminate and global damage at the …

The p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse
physiological signals in mammalian cells. In response to stress signals, perhaps the best …

The cell phenotypes of senescence and crisis operate to circumscribe the proliferative
potential of mammalian cells, suggesting that both are capable of operating in vivo to …