The Pictet-Spengler reaction (PS) is one of the most direct, efficient, and variable synthetic
method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines …

1, 2, 3, 4-Tetrahydroisoquinoline-3-carboxylic acid (Tic) is a constrained analog of
phenylalanine (Phe). The Tic unit has been identified as a core structural element present in …

The existence of rotamers in a solution of analyte complicates 1H NMR analysis, especially
when the presence of diastereomers is also possible. Organic chemists have often …

Inhibition of factor XIa (FXIa) is a novel paradigm for developing anticoagulants without
major bleeding consequences. We present the discovery of sulfated pentagalloylglucoside …

An efficient protocol has been established for β-glycosylations with 2-deoxy-2-(2, 4-
dinitrobenzenesulfonyl) amino (2dDNsNH)-glucopyranosyl/galactopyranosyl …

The discovery of a new zinc binding chemotype from screening a nonbiased fragment library
is reported. Using the orthogonal fragment screening methods of native state mass …

Trans‐β‐lactam isomers have garnered much attention as anti‐cancer microtubule targeting
agents. Currently available synthetic methods are available for the preparation of …

An efficient and straightforward approach has been established for the preparation of a new
class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini …

Multidentate Schiff base ligands derived from a selection of biphenyl‐and terphenyl
polyamines were synthesized, and their reactivity towards divalent (Ni, Cu, Zn, Cd) and …

We report here a practical and efficient synthesis of diethyl 1, 2, 3, 4‐tetrahydroisoquinoline‐
3‐phosphonate derivatives. The target compounds were prepared in good yield using a …