This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …

Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an
antioxidant against oxidative stress. As some mammals including humans cannot synthesize …

Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-
transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import …

Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold
and is also a cofactor of hydrolases that participate in the synthesis of collagen and …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …

Transporters for vitamin C and its oxidized form dehydroascorbic acid (DHA) are crucial to
maintain physiological concentrations of this important vitamin that is used in a variety of …

Large cross-sectional population studies confirm that vitamin C deficiency is common in
humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant …

Vitamin C (L-ascorbic acid) is an essential nutrient for human health, and its deficiency has
long been known to cause scurvy. Sodium-dependent vitamin C transporters (SVCTs) are …

Huntington's disease has been associated with a failure in energy metabolism and oxidative
damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it …