Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …

Natural killer T (NKT) cells recognize glycosphingolipids presented by CD1d molecules and
have been linked to defense against microbial infections. Previously defined foreign …

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems.
Recently, it has become evident that these T cells have crucial roles in the response to …

To optimize vaccination strategies, it is important to use protocols that can'jump-start'immune
responses by harnessing cells of the innate immune system to assist the expansion of …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

Globo H (GH) is a hexasaccharide specifically overexpressed on a variety of cancer cells
and therefore, a good candidate for cancer vaccine development. To identify the optimal …

Invariant natural killer T (iNKT) cells are innate-like lymphocytes recognizing CD1d-
restricted glycolipid antigens, such as α-galactosylceramide (αGC). We assessed whether …

CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted
lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads …