Alcohol and nicotine are often co-abused. As many as 80–95% of alcoholics are also
smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco …

Concurrent use of tobacco and alcohol or psychostimulants represents a major public health
concern, with use of one substance influencing consumption of the other. Co-abuse of these …

Background Factors leading to the harmful consumption of substances, like alcohol and
sucrose, involve a complex interaction of genes and the environment. While we cannot …

Understanding risk factors for substance use disorders (SUD) can facilitate medication
development for SUD treatment. While a rich literature exists discussing environmental …

Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID)
models were developed for studying rodent binge-like consumption. Traditionally, IA2BC …

In this chapter, we review the effects of global null mutant and overexpressing transgenic
mouse lines on voluntary self-administration of alcohol. We examine approximately 200 …

Alcohol and drug dependence are serious public health problems worldwide. The
prevalence of alcohol and drug dependence in the United States and other parts of the …

Polysubstance abuse of alcohol and nicotine has been overlooked in our understanding of
the neurobiology of addiction and especially in the development of novel therapeutics for its …

Evidence is emerging that neuronal nicotinic acetylcholine receptors (nAChRs) in the
mesolimbic dopamine (DA) system are involved in mediating the reinforcing effects of …

Genome wide association and animal studies have implicated genetic variations in
CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5 …