The de novo construction of a living organism is a compelling vision. Despite the astonishing
technologies developed to modify living cells, building a functioning cell “from scratch” has …

Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis,
which is an indicator of coronary artery disease (CAD). CAC refers to the accumulation of …

Throughout our lifetime, each beat of the heart requires the coordinated action of multiple
cardiac cell types. Understanding cardiac cell biology, its intricate microenvironments, and …

Genome-wide association studies (GWAS) have identified a large number of genetic loci for
coronary artery disease (CAD), with many located close to genes associated with traditional …

We have shown that lipid-associated loci discovered by genome-wide association studies
(GWAS) have pleiotropic effects on lipid metabolism, carotid intima-media thickness (CIMT) …

Abstract The prevalence of Essential Hypertension (EH) is increasing globally, and the
effectiveness of pharmacological treatments remains far from ideal. Combining Mendelian …