The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

Copy number variation of kilobase-scale genomic DNA segments, beyond
presence/absence polymorphisms, can be an important driver of adaptive traits. Resistance …

The cellular response to cancer-induced stress is one of the major aspects regulating cancer
development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone …

The lemur family of protein kinases has gained much interest in recent years as they are
involved in a variety of cellular processes including regulation of axonal transport and …

Estrogen receptor alpha (ER) is a transcriptional regulator that controls the expression of
genes related to cellular proliferation and differentiation in normal mammary tissue …

Recently, the oncogenic role of lemur tyrosine kinase 3 (LMTK3) has been well established
in different tumor types, highlighting it as a viable therapeutic target. In the present study …

More than 70% of all breast cancer cases are estrogen receptor alpha-positive (ERα). ERα
is a member of the nuclear receptor family, and its activity is implicated in the gene …

Elucidating signaling driven by lemur tyrosine kinase 3 (LMTK3) could help drug
development. Here, we solve the crystal structure of LMTK3 kinase domain to 2.1 Å …

Background Our previous genome-wide association study using the MA. 27 aromatase
inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG associated …