Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important
effector molecule of anti-tumor immunity, capable of suppressing tumor growth through …

IFNγ is a cytokine that plays a pivotal role in antitumor host immunity. IFNγ elicits potent
antitumor immunity by inducing Th1 polarization, CTL activation, and dendritic cell …

Interferon-γ is a cytokine whose biological activity is conventionally associated with
cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune …

Natural killer (NK) cells can defend an organism against a variety of threats, probably using
several different strategies to discriminate between normal and~ berrant cells. According to …

Inhibition of JAK1 or JAK2 in human tumor cells was previously shown to increase
susceptibility of these cells to NK cell lysis. In the present study, we examined the cellular …

Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor
immune responses in the elimination stage of the immunoediting paradigm. However …

The idea that NK cells can distinguish aberrant cells by recognizing'absence of the
expected', rather than'presence of the unexpected'emerged more than 25 years ago. Klas …

This article is based on a lecture presented at the Novartis Prize ceremony at the
International Congress of Immunology in July 2001. It gives a personal and historical …

Much of our understanding on resistance mechanisms to conventional cancer therapies
such as chemotherapy and radiation has focused on cell intrinsic properties that antagonize …