At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

For 200 years, the 'closed box'analogy of intracranial pressure (ICP) has underpinned
neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine …

Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

BACKGROUND AND PURPOSE: Patients with idiopathic intracranial hypertension have
transverse sinus stenosis on gadolinium-bolused MRV, but other MR imaging signs are less …

Acute moderate intensity exercise has been shown to improve cognitive performance. In
contrast, hypoxia is believed to impair cognitive performance. The detrimental effects of …

High altitude illness in its most severe form can lead to high altitude cerebral edema
(HACE). Current strategies have focused on prevention with graduated ascents …

Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion
potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms …

The pathophysiology of acute mountain sickness and high-altitude cerebral edema, the
cerebral forms of high-altitude illness, remain uncertain and controversial. Persistently …

Objective As inspired oxygen availability falls with ascent to altitude, some individuals
develop high‐altitude headache (HAH). We postulated that HAH results when hypoxia …