Oxidative stress in Parkinson's disease: Potential benefits of antioxidant supplementation

S Percário, A da Silva Barbosa… - Oxidative medicine …, 2020 - Wiley Online Library
Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology

I Pantic, J Cumic, SR Skodric, S Dugalic… - Chemico-biological …, 2021 - Elsevier
Abstract Oxidopamine (6-hydroxydopamine, 6-OHDA) is a toxin commonly used for the
creation of experimental animal models of Parkinson's disease, attention-deficit hyperactivity …

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in …

K Yıldızhan, M Nazıroğlu - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is one of most common neurodegenerative diseases.
Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and …

Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons

R Sheta, M Teixeira, W Idi, M Pierre… - Scientific Reports, 2022 - nature.com
The use of human derived induced pluripotent stem cells (hiPSCs) differentiated to
dopaminergic (DA) neurons offers a valuable experimental model to decorticate the cellular …

Oxidopamine-Induced Nuclear Alterations Quantified Using Advanced Fractal Analysis: Random Forest Machine Learning Approach

I Pantic, N Topalovic, PR Corridon, J Paunovic - Fractal and Fractional, 2023 - mdpi.com
Fractal analysis (FA) is a contemporary computational technique that can assist in identifying
and assessing nuanced structural alterations in cells and tissues after exposure to certain …

[HTML][HTML] Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?

I Roato, M Visca, F Mussano - Biomedicines, 2024 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are involved in the maintenance and regeneration
of a large variety of tissues due to their stemness and multi-lineage differentiation capability …

Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway

Y Xu, P Fan, L Liu, X Xu, L Zhang, J Wang… - Journal of Zhejiang …, 2023 - Springer
Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of
their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting …

N-acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase

R El-Habta, S af Bjerkén, A Virel - Neurological Research, 2024 - Taylor & Francis
ABSTRACT Objectives Current treatments for Parkinson's disease using pharmacological
approaches alleviate motor symptoms but do not prevent neuronal loss or dysregulation of …

Hollow Gold Nanoparticles Loaded with L‐Buthionine‐Sulfoximine as a Novel Nanomedicine for In Vitro Cancer Cell Therapy

M Liu, W Li, R Xu, X Jiang, A Liu - Journal of Nanomaterials, 2021 - Wiley Online Library
A novel nanomedicine, constructed by simultaneously binding L‐buthionine‐sulfoximine
(BSO) and thiolated polyethylene glycol (PEG) to the surface of 100 nm hollow gold …

The role of reactive oxygen species in the immunity induced by nano-pulse stimulation

S Guo, NI Burcus, M Scott, Y Jing, I Semenov - Scientific reports, 2021 - nature.com
Reactive oxygen species (ROS) are byproducts of tumor cells treated with Nano-Pulse
Stimulation (NPS). Recently, ROS have been suggested as a contributing factor in …