Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for
degrading the secondary messengers 3′, 5′-cyclic nucleotides cAMP and cGMP. Their …

Cardiovascular diseases are important causes of mortality and morbidity worldwide.
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …

An attractive strategy to overcome multidrug resistance in cancer chemotherapy is to
suppress P-glycoprotein (P-gp), which is a pump overproduced in cancer cells to remove …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …

Objective—The present study is aimed at investigating the interaction of TRPV4 with TRPC1
and the functional role of such an interaction in flow-induced Ca2+ influx. Hemodynamic …

The second messenger cAMP plays a central role in mediating vascular smooth muscle
relaxation in response to vasoactive transmitters and in strengthening endothelial cell–cell …

Transient receptor potential canonical 3/6/7 (TRPC3/6/7) are highly homologous receptor-
operated nonselective cation channels. Despite their physiological significance, very few …

Background and Purpose Pulmonary arteries (PA s) are innervated, but little is known about
the role of neuronal axis in pulmonary hypertension (PH). Here, we have examined the role …

Key points• Relaxation of vascular smooth muscle, which increases blood vessel diameter,
is often mediated through vasodilator‐induced elevations of intracellular 3′‐5′‐cyclic …

The matrix glycoprotein thrombospondin-1 (THBS1) modulates nitric oxide (NO) signaling in
endothelial cells. A high-salt diet induces deficiencies of NO production and bioavailability …