In patients with glioblastoma, the average survival time with current treatments is short,
mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in …

Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis
has increased exponentially in recent years. Advanced “omics” coupled with machine …

Abstract The imidazobenzoxazin-5-thione MV1035, synthesized as a new sodium channel
blocker, has been tested on tumoral cells that differ for origin and for expressed Na V pool …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

Glioblastoma multiforme (GBM) is a particularly aggressive and malignant type of brain
tumor, notorious for its high recurrence rate and low survival rate. The treatment of GBM is …

Ion transport across the cell membrane mediated by channels and carriers participate in the
regulation of tumour cell survival, death and motility. Moreover, the altered regulation of …

A major breakthrough in neuroscience has been the realization in the last decades that the
dogmatic view of astroglial cells as being merely fostering and buffering elements of the …

Despite the multidisciplinary integration in the therapeutic management of glioblastoma
multiforme (GBM), the prognosis of GBM patients is poor. There is growing recognition that …

Sodium magnetic resonance (MR) imaging in humans has promised metabolic information
that can improve medical management in important diseases. This technology has yet to find …

Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …