Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK‐8628 in malignant pleural mesothelioma xenografts

R Vázquez, SA Licandro… - … Journal of Cancer, 2017 - Wiley Online Library
It has recently been reported that a large proportion of human malignant pleural
mesothelioma (MPM) cell lines and patient tissue samples present high expression of the c …

Prenatal folate deficiency impairs sociability and memory/recognition in mice offspring

M Yoshikawa, K Suemaru - Brain Research, 2024 - Elsevier
Folate is essential for the normal growth and development of the fetus. Folic acid
supplementation during the fetal period affects postnatal brain development and reduces the …

Novel insights in folate receptors and transporters: implications for disease and treatment of immune diseases and cancer

G Jansen, GJ Peters - Pteridines, 2015 - degruyter.com
Folate receptors and transporters as well as folate enzymes play an essential role in human
disease and form important targets for the treatment of immune diseases and cancer. To …

Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: implications to folate metabolon compartmentalization

M Stark, S Raz, YG Assaraf - Journal of Proteomics, 2021 - Elsevier
Folates are essential for nucleotide biosynthesis, amino acid metabolism and cellular
proliferation. Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-ɣ …

The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene

M Miller - 2022 - search.proquest.com
Chronic exposure to inorganic arsenic (iAs) is a public health concern and is associated with
type 2 diabetes. iAs metabolism consists of methylation reactions catalyzed by arsenic …