Endometriosis is a chronic and debilitating condition affecting∼ 10% of women.
Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options …

Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …

The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …

Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C
(GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with …

Pain involving thoracic, abdominal, or pelvic organs is a common cause for physician
consultations, including one‐third of chronic pain patients who report that visceral organs …

Chronic abdominal pain accompanying intestinal inflammation emerges from the
hyperresponsiveness of neuronal, immune and endocrine signaling pathways within the …

Poor oral availability and susceptibility to reduction and protease degradation is a major
hurdle in peptide drug development. However, drugable receptors in the gut present an …

Brown and white adipose tissues are essential for maintenance of proper energy balance
and metabolic health. In order to function efficiently, these tissues require both endocrine …

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal
or avoidance of tissue damage. While pain arises from both the skin and viscera, we …

Irritable bowel syndrome (IBS) patients suffer from chronic abdominal pain and
extraintestinal comorbidities, including overactive bladder (OAB) and interstitial …