[HTML][HTML] An analysis of multidrug multicomponent crystals as tools for drug development

ON Kavanagh - Journal of Controlled Release, 2024 - Elsevier
In a typical tablet or capsule formulation, the active drug is often present as a crystalline
solid. This solid emerges from the relationships between the individual atoms within the …

[HTML][HTML] The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential

L Wu, H Tang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases
of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of …

Speeding Up the Cocrystallization Process: Machine Learning-Combined Methods for the Prediction of Multicomponent Systems

R Birolo, F Bravetti, E Alladio, E Priola… - Crystal Growth & …, 2023 - ACS Publications
Pharmaceutical cocrystals are crystalline materials composed of at least two molecules, ie,
an active pharmaceutical ingredient (API) and a coformer, assembled by noncovalent forces …

[HTML][HTML] Combination Drug Therapy for the Management of Chronic Neuropathic Pain

S Boccella, L De Filippis, C Giorgio, L Brandolini… - Biomolecules, 2023 - mdpi.com
Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of
disability which is challenging to treat. Several distinct classes of drugs are currently used for …

Synthesis of naringenin-betaine cocrystal by gas antisolvent technique and cell models for in vitro permeation studies

PV Oliveira, GPS Aguiar, AM Siebel, LG Müller… - Journal of Drug Delivery …, 2024 - Elsevier
Naringenin (NRG) is a flavanone characterized by potential neuroprotective properties, even
if low water solubility and poor oral bioavailability limit the ability of this compound to target …

Fabricating Ultra-Narrow Precision Slit Structures with Periodically Reducing Current Over-Growth Electroforming

X Yang, X Zhang, P Ming, Y Li, W Wang, Y Zhang, Z Li… - Micromachines, 2023 - mdpi.com
An ultra-narrow precision slit with a width of less than ten micrometers is the key structure of
some optical components, but the fabrication of these structures is still very difficult to …