Data-driven methods for present and future pandemics: Monitoring, modelling and managing

T Alamo, DG Reina, PM Gata, VM Preciado… - Annual Reviews in …, 2021 - Elsevier
This survey analyses the role of data-driven methodologies for pandemic modelling and
control. We provide a roadmap from the access to epidemiological data sources to the …

Melatonin Suppresses Macrophage M1 Polarization and ROS‐Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A‐Induced Acute Lung Injury

MM Xu, JY Kang, S Ji, YY Wei, SL Wei… - Oxidative Medicine …, 2022 - Wiley Online Library
Influenza virus infection is one of the strongest pathogenic factors for the development of
acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). However, the underlying …

Interaction among inflammasome, PANoptosise, and innate immune cells in infection of influenza virus: Updated review

L Wei, X Wang, H Zhou - Immunity, Inflammation and Disease, 2023 - Wiley Online Library
Background Influenza virus (IV) is a leading cause of respiratory tract infections, eliciting
responses from key innate immune cells such as Macrophages (MQs), Neutrophils, and …

The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infection

E Barreto-Duran, A Szczepański… - Frontiers in …, 2022 - frontiersin.org
The first line of antiviral immune response in the lungs is secured by the innate immunity.
Several cell types take part in this process, but airway macrophages (AMs) are among the …

Modeling and stability analysis of within-host IAV/SARS-CoV-2 coinfection with antibody immunity

AM Elaiw, RS Alsulami, AD Hobiny - Mathematics, 2022 - mdpi.com
Studies have reported several cases with respiratory viruses coinfection in hospitalized
patients. Influenza A virus (IAV) mimics the Severe Acute Respiratory Syndrome …

Lignans from Mosla scabra Ameliorated Influenza A Virus‐Induced Pneumonia via Inhibiting Macrophage Activation

W Cai, LR Wu, SL Zhang - Evidence‐Based Complementary …, 2022 - Wiley Online Library
The lower respiratory tract infection, induced by influenza virus, coronaviruses, and
respiratory syncytial virus, remains a serious threat to human health that can cause a global …

Quantitatively Mapping Immune Control during Influenza

JJA Weaver, AM Smith - Current Opinion in Systems Biology, 2024 - Elsevier
Host immune responses play a pivotal role in defending against influenza viruses. The
activation of various immune components, such as interferon, macrophages, and CD8+ T …

[HTML][HTML] A nonlinear mathematical model for exploring the optimal cost-effective therapeutic strategies and within-host viral infections spread dynamics

A Abidemi, M Alnegga, TO Alade - Healthcare Analytics, 2024 - Elsevier
This study presents a nonlinear mathematical model to capture the constant rates of three
different target cells class-specific drug therapeutic measures (namely, drug therapy for …

Calcitriol attenuates poly (I: C)-induced lung injury in obese mice via modulating toll-like receptor 3-and renin-angiotensin system-associated signal pathways

CL Yeh, JM Wu, KY Chen, MH Wu, PJ Yang… - International …, 2024 - Elsevier
This study investigated the effects of calcitriol on polyinosinic-polycytidylic acid (poly (I: C))-
induced acute lung injury (ALI) and its association with Toll-like receptor 3 (TLR3) and renin …

Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes

S Sahoo, K Hari, S Jhunjhunwala, MK Jolly - BioRxiv, 2020 - biorxiv.org
The disease caused by SARS-CoV-2 is a global pandemic that threatens to bring long-term
changes worldwide. Approximately 80% of infected patients are asymptomatic or have mild …