Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
Polygenic scores in psychiatry: on the road from discovery to implementation
The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
Study protocol comparing the ethical, psychological and socio-economic impact of personalised breast cancer screening to that of standard screening in the “My …
Abstract Background The MyPeBS study is an ongoing randomised controlled trial testing
whether a risk-stratified breast cancer screening strategy is non-inferior, or eventually …
whether a risk-stratified breast cancer screening strategy is non-inferior, or eventually …
Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study
X Yang, M Eriksson, K Czene, A Lee, G Leslie… - Journal of medical …, 2022 - jmg.bmj.com
Background The multifactorial Breast and Ovarian Analysis of Disease Incidence and
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …
[HTML][HTML] Polygenic risk scores for prediction of breast cancer risk in Asian populations
Abstract Purpose Non-European populations are under-represented in genetics studies,
hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed …
hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed …
[HTML][HTML] Envisioning the Future of Personalized Medicine: Role and Realities of Digital Twins
A Vallée - Journal of Medical Internet Research, 2024 - jmir.org
Digital twins have emerged as a groundbreaking concept in personalized medicine, offering
immense potential to transform health care delivery and improve patient outcomes. It is …
immense potential to transform health care delivery and improve patient outcomes. It is …
Incorporating alternative polygenic risk scores into the BOADICEA breast cancer risk prediction model
N Mavaddat, L Ficorella, T Carver, A Lee… - … Biomarkers & Prevention, 2023 - AACR
Background: The multifactorial risk prediction model BOADICEA enables identification of
women at higher or lower risk of developing breast cancer. BOADICEA models genetic …
women at higher or lower risk of developing breast cancer. BOADICEA models genetic …
The WISDOM study: a new approach to screening can and should be tested
In the recent opinion piece by Dr. Kopans, he takes exception to the WISDOM (Women
Informed to Screen Depending on Measures of Risk) study, the on-going pragmatic trial of …
Informed to Screen Depending on Measures of Risk) study, the on-going pragmatic trial of …
Implementing risk-stratified breast screening in England: an agenda setting meeting
L McWilliams, DG Evans, K Payne, F Harrison… - 2022 - mdpi.com
Simple Summary A risk-stratified approach to breast cancer screening has gained
international interest as a mechanism to better balance the benefits, harms and costs of …
international interest as a mechanism to better balance the benefits, harms and costs of …
Delineation and detection of breast cancer using novel label-free fluorescence
A Mahmoud, YH El-Sharkawy - BMC Medical Imaging, 2023 - Springer
Background Accurate diagnosis of breast cancer (BC) plays a crucial role in clinical
pathology analysis and ensuring precise surgical margins to prevent recurrence. Methods …
pathology analysis and ensuring precise surgical margins to prevent recurrence. Methods …