Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review

J Lu, K Karkouti, M Peer, M Englesakis… - Canadian Journal of …, 2023 - Springer
Purpose Cold-stored platelets (CSP) are an increasingly active topic of international
research. They are maintained at 1–6° C, in contrast to standard room-temperature platelets …

Frozen and cold-stored platelets: reconsidered platelet products

T Jimenez-Marco, A Castrillo, F Hierro-Riu, V Vicente… - Platelets, 2022 - Taylor & Francis
Platelet transfusion, both prophylactic and therapeutic, is a key element in modern medicine.
Currently, the standard platelet product for clinical use is platelet concentrates at room …

Cold-stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism

SM Shea, JA Reisz, EP Mihalko, KC Rahn… - Journal of Thrombosis …, 2024 - Elsevier
Background Platelet (PLT) product transfusion is a life-saving therapy for actively bleeding
patients. There is an urgent need to maintain PLT function and extend shelf life to improve …

Refrigeration of apheresis platelets in platelet additive solution (PAS‐E) supports in vitro platelet quality to maximize the shelf‐life

L Johnson, S Vekariya, B Wood, S Tan, C Roan… - …, 2021 - Wiley Online Library
Background Refrigeration, or cold‐storage, of platelets may be beneficial to extend the
limited shelf‐life of conventionally stored platelets and support transfusion protocols in rural …

Quantitative increases of extracellular vesicles in prolonged cold storage of platelets increases the potential to enhance fibrin clot formation

J Nash, A Davies, CV Saunders… - Transfusion …, 2023 - Wiley Online Library
Background Platelet derived extracellular vesicles (EVs) display a pro‐coagulant phenotype
and are generated throughout platelet concentrate (PC) storage. Cold storage (CS) of PCs is …

Storage temperature determines platelet GPVI levels and function in mice and humans

J Miles, SL Bailey, AM Obenaus, MY Mollica… - Blood …, 2021 - ashpublications.org
Platelets are currently stored at room temperature before transfusion to maximize circulation
time. This approach has numerous downsides, including limited storage duration, bacterial …

The role of sodium citrate during extended cold storage of platelets in platelet additive solutions

L Johnson, C Roan, P Lei, PC Spinella… - Transfusion, 2023 - Wiley Online Library
Background Cold‐stored platelets are increasingly being used to treat bleeding. Differences
in manufacturing processes and storage solutions can affect platelet quality and may …

The missing pieces to the cold-stored platelet puzzle

H Zhao, DV Devine - International Journal of Molecular Sciences, 2022 - mdpi.com
Cold-stored platelets are making a comeback. They were abandoned in the late 1960s in
favor of room-temperature stored platelets due to the need for longer post-transfusion …

Postoperative transfusions following administration of delayed cold stored platelets vs. room temperature platelets in cardiac surgery: A retrospective cohort study

AM Klompas, S Zec, AC Hanson, T Weister… - …, 2023 - pmc.ncbi.nlm.nih.gov
Background: Delayed cold-storage of room temperature platelets may extend shelflife from 5
to 14 days. We hypothesized the use of delayed cold-stored platelets in cardiac surgery …

Precision platelet transfusion medicine is needed to improve outcomes

JR Coleman, PC Spinella - Hospital Pediatrics, 2023 - publications.aap.org
In this retrospective cohort study from a large administrative database in this issue of
Hospital Pediatrics, Lang et al 1 examine epidemiologic trends and clinical outcomes of 4 …