Large bone defects are usually managed by replacing lost bone with non-biological
prostheses or with bone grafts that come from the patient or a donor. Bone tissue …

Gene therapy directly targets mutations causing disease, allowing for a specific treatment at
a molecular level. Adeno-associated virus (AAV) has been of increasing interest as a gene …

Engineered living materials (ELMs) are the most relevant contemporary revolution in
materials science and engineering and aim to outperform current examples of" smart," …

Gene therapy is one of the most promising approaches in regenerative medicine. Gene-
activated matrices provide stable gene expression and the production of osteogenic proteins …

Tissue engineering using adult human mesenchymal stem cells (MSCs) seeded within
biomaterial scaffolds has shown the potential to enhance bone healing. Recently, we have …

Natural and synthetic hydrogel scaffolds containing bioactive components are increasingly
used in solving various tissue engineering problems. The encapsulation of DNA-encoding …

Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the
intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of …

The effect of molecular characteristics and morphology on mechanical performance and
biocompatibility of PLA-based spongious scaffolds was studied. PLLA and PDLLA with …

In this study, we introduce electrospun polydioxanone (PDO) nonwoven fabrics as a platform
for the delivery of adeno-associated virus (AAV) vectors for transduction and genome editing …

Biomaterial-assisted gene therapy is a promising strategy for the treatment of various
musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons …