Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the 'Bystander' Activation of Memory CD8+ T …
G Anderson - International Journal of Molecular Sciences, 2023 - mdpi.com
Type 1 diabetes mellitus (T1DM) arises from the failure of pancreatic β-cells to produce
adequate insulin, usually as a consequence of extensive pancreatic β-cell destruction …
adequate insulin, usually as a consequence of extensive pancreatic β-cell destruction …
Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice
D Kasinathan, Z Guo, DC Sarver, GW Wong, S Yun… - Diabetes, 2024 - Am Diabetes Assoc
Type 1 diabetes (T1D) is an autoimmune disease in which pathogenic lymphocytes target
autoantigens expressed in pancreatic islets, leading to the destruction of insulin-producing β …
autoantigens expressed in pancreatic islets, leading to the destruction of insulin-producing β …
A practical and robust method to evaluate metabolic fluxes in primary pancreatic islets
DS Rocha, AC Manucci, A Bruni-Cardoso… - Molecular …, 2024 - Elsevier
Objective Evaluation of mitochondrial oxygen consumption and ATP production is important
to investigate pancreatic islet pathophysiology. Most studies use cell lines due to difficulties …
to investigate pancreatic islet pathophysiology. Most studies use cell lines due to difficulties …
Ophiopogonin D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by hydrogen peroxide through Keap1/Nrf2/ARE pathway in …
H Zhang, X Kang, J Ruan, L Ma, W Peng… - Journal of …, 2023 - journals.lww.com
Diabetes mellitus (DM) is a metabolic disease characterized by high blood sugar. Due to its
complex pathogenesis, no effective drugs have been found so far. Ophiopogonin D (OP-D) …
complex pathogenesis, no effective drugs have been found so far. Ophiopogonin D (OP-D) …
A practical and robust method to evaluate metabolic fluxes in pancreatic islets
DS Rocha, AC Manucci, A Bruni-Cardoso… - bioRxiv, 2023 - biorxiv.org
Aims/hypothesis Efficient mitochondrial oxidative phosphorylation is essential for pancreatic
beta cell responses to nutrient levels. Consequently, the evaluation of mitochondrial oxygen …
beta cell responses to nutrient levels. Consequently, the evaluation of mitochondrial oxygen …