Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …

TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …

Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …

PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …

Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by
specific adaptor proteins. How and why cells use numerous different export adaptors is …

Protein degradation plays important roles in biological processes and is tightly regulated.
Further, targeted proteolysis is an emerging research tool and therapeutic strategy …

GGGGCC repeat expansions of C9orf72 represent the most common genetic variant of
amyotrophic lateral sclerosis and frontotemporal degeneration, but the mechanism of …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Summary mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein
particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP …

GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have …