Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms
of life. In recent years, the discovery of new signalling molecules in bacteria and archaea, as …

Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger,
by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I interferon (IFN) …

Nucleotide signaling molecules are important messengers in key pathways that allow
cellular responses to changing environments. Canonical secondary signaling molecules act …

The mycobacterial repressor, DarR, a TetR family regulator (TFR), was the first transcription
regulator shown to bind c-di-AMP. However, the molecular basis for this interaction and the …

Cyclic di-adenosine monophosphate (c-di-AMP) is a broadly conserved second messenger
required for bacterial growth and infection. However, the molecular mechanisms of c-di-AMP …