Genetic variation in low-to-medium-affinity Fcγ receptors: functional consequences, disease associations, and opportunities for personalized medicine

SQ Nagelkerke, DE Schmidt, M De Haas… - Frontiers in …, 2019 - frontiersin.org
Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies

C Gillis, A Gouel-Chéron, F Jönsson… - Frontiers in …, 2014 - frontiersin.org
The biological activities of human IgG antibodies predominantly rely on a family of receptors
for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5 …

Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in Europe

J Kerr, I Quinti, M Eibl, H Chapel, PJ Späth… - Frontiers in …, 2014 - frontiersin.org
The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody
deficiencies, an aging population, and new indications. This review aims to examine the …

Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease

SQ Nagelkerke, CE Tacke, WB Breunis… - Frontiers in …, 2019 - frontiersin.org
The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding
immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus …

European consensus proposal for immunoglobulin therapies

WAC Sewell, J Kerr, ME Behr‐Gross, HH Peter… - 2014 - Wiley Online Library
The use of immunoglobulin (Ig) preparations (intravenous, IVIg, subcutaneous, SCIg) for
replacement and immunomodulation therapy worldwide has tripled in the past 20 years and …

FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery …

P Uittenbogaard, SA Netea, MWT Tanck… - Frontiers in …, 2024 - frontiersin.org
Introduction Kawasaki disease (KD) is a pediatric vasculitis that can result in coronary artery
aneurysm (CAA) formation, which is a dangerous complication. Treatment with intravenous …

[HTML][HTML] Intravenous immunoglobulin, pharmacogenomics, and Kawasaki disease

HC Kuo, YW Hsu, MS Wu, SC Chien, SF Liu… - Journal of Microbiology …, 2016 - Elsevier
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and it is therefore worth
examining the multifactorial interaction of genes and environmental factors. Targeted …

Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease

S Shrestha, HW Wiener, H Kajimoto… - Frontiers in …, 2024 - frontiersin.org
Introduction Kawasaki disease (KD) is a diffuse vasculitis in children. Response to high dose
intravenous gamma globulin (IVIG), the primary treatment, varies according to genetic …

Polymorphisms of immunoglobulin receptors and the effects on clinical outcome in cancer immunotherapy and other immune diseases: a general review

T Kaifu, A Nakamura - International Immunology, 2017 - academic.oup.com
Receptors for the Fc domain of immunoglobulins [Fc receptors (FcRs)] are essential for the
maintenance of antibody-mediated immune responses. FcRs consist of activating-and …

The state of play in tools for predicting immunoglobulin resistance in Kawasaki disease

MMH Guo, HC Kuo - Expert Review of Clinical Immunology, 2023 - Taylor & Francis
Introduction Intravenous immunoglobulin (IVIG) resistance is an independent risk factor for
the development of coronary artery lesions (CAL) in patients with Kawasaki disease (KD) …