Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …

Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Breast cancer is the most frequent cancer among women worldwide. Therapeutic strategies
to prevent or treat metastatic disease are still inadequate although great progress has been …

Despite a continuing debate about the existence of cancer stem cells (CSCs), recent
discoveries have provided further support for their existence and their roles in drug …

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Aberrant regulation of Wnt signaling is a common theme seen across many tumor types.
Decades of research have unraveled the epigenetic and genetic alterations that result in …

Breast cancers have been increasingly recognized as malignancies displaying frequent
inter-and intra-tumor heterogeneity. This heterogeneity is represented by diverse subtypes …

A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …