Benzodiazepines in the management of seizures and status epilepticus: a review of routes of delivery, pharmacokinetics, efficacy, and tolerability

R Kienitz, L Kay, I Beuchat, S Gelhard… - CNS drugs, 2022 - Springer
Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

Guidelines for the evaluation and management of status epilepticus

GM Brophy, R Bell, J Claassen, B Alldredge, TP Bleck… - Neurocritical care, 2012 - Springer
Status epilepticus (SE) treatment strategies vary substantially from one institution to another
due to the lack of data to support one treatment over another. To provide guidance for the …

Refractory status epilepticus: frequency, risk factors, and impact on outcome

SA Mayer, J Claassen, J Lokin… - Archives of …, 2002 - jamanetwork.com
Background Refractory status epilepticus (RSE) is a life-threatening condition in which
seizures do not respond to first-and second-line anticonvulsant drug therapy. How often …

Propofol: therapeutic indications and side-effects

PE Marik - Current pharmaceutical design, 2004 - ingentaconnect.com
Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely
used for the induction and maintenance of anesthesia and for sedation in the intensive care …

EFNS guideline on the management of status epilepticus in adults

H Meierkord, P Boon, B Engelsen… - European journal of …, 2010 - Wiley Online Library
The objective of the current article was to review the literature and discuss the degree of
evidence for various treatment strategies for status epilepticus (SE) in adults. We searched …

Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review

J Claassen, LJ Hirsch, RG Emerson, SA Mayer - Epilepsia, 2002 - Wiley Online Library
Background: New continuous infusion antiepileptic drugs (cIV‐AEDs) offer alternatives to
pentobarbital for the treatment of refractory status epilepticus (RSE). However, no …

Status epilepticus: pathophysiology and management in adults

JWY Chen, CG Wasterlain - The Lancet Neurology, 2006 - thelancet.com
Summary As in Clark and Prout's classic work, we identify three phases of generalised
convulsive status epilepticus, which we call impending, established, and subtle. We review …

Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit

M Holtkamp, J Othman, K Buchheim… - Journal of Neurology …, 2005 - jnnp.bmj.com
Objective: To assess risk factors and prognosis in patients with refractory status epilepticus
(RSE). Methods: We retrospectively analysed all episodes of status epilepticus (SE) treated …

Treatment of refractory convulsive status epilepticus: a comprehensive review by the American Epilepsy Society Treatments Committee

DG Vossler, JL Bainbridge, JG Boggs… - Epilepsy …, 2020 - journals.sagepub.com
Purpose: Established tonic–clonic status epilepticus (SE) does not stop in one-third of
patients when treated with an intravenous (IV) benzodiazepine bolus followed by a loading …

Predictors of outcome in refractory status epilepticus

SE Hocker, JW Britton, JN Mandrekar… - JAMA …, 2013 - jamanetwork.com
Objective To further characterize the demographics, outcomes, and prognostic factors for
refractory status epilepticus (RSE). Design Retrospective analysis of all the episodes of RSE …