Acetohydroxyacid synthases: evolution, structure, and function
Y Liu, Y Li, X Wang - Applied microbiology and biotechnology, 2016 - Springer
Acetohydroxyacid synthase, a thiamine diphosphate-dependent enzyme, can condense
either two pyruvate molecules to form acetolactate for synthesizing L-valine and L-leucine or …
either two pyruvate molecules to form acetolactate for synthesizing L-valine and L-leucine or …
Deciphering survival strategies: Oxidative stress and microbial interplay in Eisenia fetida under tetracycline contamination
Y Ning, S Wang, Y Sun, S Zhang, Y Wen, D Zou… - Science of The Total …, 2024 - Elsevier
Soil contamination resulting from residual antibiotics presents a pressing need to
understand the survival mechanisms of soil organisms in polluted environments. This study …
understand the survival mechanisms of soil organisms in polluted environments. This study …
Recent Progress in the Synthesis of α‐Hydroxy Carbonyl Compounds with ThDP‐dependent Carboligases
Thiamine diphosphate (ThDP) dependent carboligases catalyze the formation of carbon‐
carbon bonds. These enzymes are prominent biocatalysts for the production of valuable α …
carbon bonds. These enzymes are prominent biocatalysts for the production of valuable α …
A possible role for the chloroplast pyruvate dehydrogenase complex in plant glycolate and glyoxylate metabolism
Glyoxylate is a peroxisomal intermediate of photorespiration, the recycling pathway for 2-
phosphoglycolate (2-PG) produced by the oxygenase activity of Rubisco. Under hot and dry …
phosphoglycolate (2-PG) produced by the oxygenase activity of Rubisco. Under hot and dry …
Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4′-aminopyrimidinium and 1′, 4′-iminopyrimidine tautomeric …
Glyoxylate carboligase (GCL) is a thiamin diphosphate (ThDP)-dependent enzyme, which
catalyzes the decarboxylation of glyoxylate and ligation to a second molecule of glyoxylate …
catalyzes the decarboxylation of glyoxylate and ligation to a second molecule of glyoxylate …
Significant Catalytic Roles for Glu47 and Gln 110 in All Four of the C− C Bond-Making and-Breaking Steps of the Reactions of Acetohydroxyacid Synthase II
M Vyazmensky, A Steinmetz, D Meyer, R Golbik… - Biochemistry, 2011 - ACS Publications
Acetohydroxy acid synthase (AHAS) is a thiamin diphosphate (ThDP)-dependent enzyme
that catalyzes the first common step in the biosynthesis of branched-chain amino acids …
that catalyzes the first common step in the biosynthesis of branched-chain amino acids …
Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase
IA Baig, JY Moon, MS Kim, BS Koo, MY Yoon - Enzyme and microbial …, 2014 - Elsevier
Mycobacterium tuberculosis AHAS is a potential target for the development of novel anti-
tuberculosis agents. Silico analysis showed that conserved His84 and Gln86 residues lie in …
tuberculosis agents. Silico analysis showed that conserved His84 and Gln86 residues lie in …
Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase
V Gedi, JY Moon, WM Lim, MY Lee, SC Lee… - Enzyme and microbial …, 2011 - Elsevier
Acetohydroxyacid synthase (AHAS), a potential target for antimicrobial agents, catalyzes the
first common step in the biosynthesis of branched-chain amino acids. The gene coding for …
first common step in the biosynthesis of branched-chain amino acids. The gene coding for …
Molecular evolution of acetohydroxyacid synthase in bacteria
Y Liu, Y Li, X Wang - MicrobiologyOpen, 2017 - Wiley Online Library
Acetohydroxyacid synthase (AHAS) is the key enzyme in the biosynthetic pathways of
branched chain amino acids in bacteria. Since it does not exist in animal and plant cells …
branched chain amino acids in bacteria. Since it does not exist in animal and plant cells …
Theoretical study of the catalytic mechanism of glyoxylate carboligase and its mutant V51E
J Zhang, Y Liu - Theoretical Chemistry Accounts, 2017 - Springer
Glyoxylate carboligase (GCL) catalyzes the ligation of two molecules of glyoxylate to form
tartronate semialdehyde (TSA) and carbon dioxide. GCL is unique among ThDP-dependent …
tartronate semialdehyde (TSA) and carbon dioxide. GCL is unique among ThDP-dependent …