Chalcone: a promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Molecular structural aspects of organic corrosion inhibitors: Influence of–CN and–NO2 substituents on designing of potential corrosion inhibitors for aqueous media

C Verma, EE Ebenso, MA Quraishi - Journal of Molecular Liquids, 2020 - Elsevier
The organic compounds containing–CN and–NO 2 substituents are extensively used as
metal corrosion inhibitors. The–CN and–NO 2 substituents are electron withdrawing in …

Water: an underestimated solvent for amide bond-forming reactions

S Hazra, F Gallou, S Handa - ACS Sustainable Chemistry & …, 2022 - ACS Publications
Construction of the amide/peptide bond is one of the most encountered transformations in
the pharmaceutical and chemical industries. Traditional protocols rely on the use of …

[HTML][HTML] Environmental pollution with psychiatric drugs

J Argaluza, S Domingo-Echaburu, G Orive… - World journal of …, 2021 - ncbi.nlm.nih.gov
Among all contaminants of emerging interest, drugs are the ones that give rise to the
greatest concern. Any of the multiple stages of the drug's life cycle (production, consumption …

Drug pollution & sustainable development goals

S Domingo-Echaburu, LM Dávalos, G Orive… - Science of The Total …, 2021 - Elsevier
Abstract The United Nations set “The 2030 Agenda for Sustainable Development,” which
includes the Sustainable Development Goals (SDGs), a collection of 17 global goals …

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery

KA Hughes, B Misra, M Maghareh, S Bobbala - Nano Research, 2023 - Springer
Drug delivery has made tremendous advances in the last decade. Targeted therapies are
increasingly common, with intracellular delivery highly impactful and sought after …

Simultaneous improvement of dissolution behavior and oral bioavailability of antifungal miconazole via cocrystal and salt formation

KV Drozd, AN Manin, DE Boycov, GL Perlovich - Pharmaceutics, 2022 - mdpi.com
Miconazole shows low oral bioavailability in humans due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as antifungal, anti …

Laccases: Versatile biocatalysts for the synthesis of heterocyclic cores

AC Sousa, LO Martins, MP Robalo - Molecules, 2021 - mdpi.com
Laccases are multicopper oxidases that have shown a great potential in various
biotechnological and green chemistry processes mainly due to their high relative non …

Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds

R Yadav, D Meena, K Singh, R Tyagi, Y Yadav… - RSC …, 2023 - pubs.rsc.org
This review highlights the recent synthetic developments of benzothiazole based anti-
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …

Evolution of acridines and xanthenes as a core structure for the development of antileishmanial agents

CFM Silva, DCGA Pinto, PA Fernandes, AMS Silva - Pharmaceuticals, 2022 - mdpi.com
Nowadays, leishmaniasis constitutes a public health issue in more than 88 countries,
affecting mainly people from the tropics, subtropics, and the Mediterranean area. Every year …