Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

Caspases are crucial mediators of programmed cell death (apoptosis). Among them,
caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many …

Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell
suicide program critical for development, tissue homeostasis, and protection against …

We report here that BID, a BH3 domain–containing proapoptotic Bcl2 family member, is a
specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway. While full …

A variety of physiological death signals, as well as pathological cellular insults, trigger the
genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis …