Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

MicroRNAs as regulatory elements in immune system logic

A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

SOX4: epigenetic regulation and role in tumorigenesis

H Hanieh, EA Ahmed, R Vishnubalaji… - Seminars in cancer …, 2020 - Elsevier
Sex-determining region Y-related (SRY) high-mobility group box 4 (SOX4) is a member of
the group C subfamily of SOX transcription factors and promotes tumorigenesis by endowing …

Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination

Y Miyashita, T Yoshida, Y Takagi, H Tsukamoto… - npj Vaccines, 2022 - nature.com
Abstract mRNA-based vaccines have been used globally to eradicate the coronavirus-
disease 2019 (COVID-19) pandemic. Vaccine efficacy and adverse reactions depend on …

The mechanism of stem cell aging

L Mi, J Hu, N Li, J Gao, R Huo, X Peng, N Zhang… - Stem cell reviews and …, 2022 - Springer
Stem cells have self-renewal ability and multi-directional differentiation potential. They have
tissue repair capabilities and are essential for maintaining the tissue homeostasis. The …

Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunities

SP Kabekkodu, V Shukla, VK Varghese… - Wiley …, 2020 - Wiley Online Library
MiRNAs are class of noncoding RNA important for gene expression regulation in many
plants, animals and viruses. MiRNA clusters contain a set of two or more miRNA encoding …

MicroRNAs: Tiny regulators of gene expression with pivotal roles in normal B-Cell development and B-Cell chronic lymphocytic leukemia

K Katsaraki, P Karousi, PI Artemaki, A Scorilas… - Cancers, 2021 - mdpi.com
Simple Summary The involvement of miRNAs in physiological cellular processes has been
well documented. The development of B cells, which is dictated by a miRNA-transcription …

A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci

X Chang, M March, F Mentch, K Nguyen… - Journal of Allergy and …, 2022 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the
esophagus marked by eosinophilic infiltration. Cumulative evidence indicates that the risk of …

miRNA-mediated control of B cell responses in immunity and SLE

SL Schell, ZSM Rahman - Frontiers in immunology, 2021 - frontiersin.org
Loss of B cell tolerance is central to autoimmune diseases such as systemic lupus
erythematosus (SLE). As such, the mechanisms involved in B cell development, maturation …