Engineering versatile bacteria‐derived outer membrane vesicles: an adaptable platform for advancing cancer immunotherapy

Z Luo, X Cheng, B Feng, D Fan, X Liu, R Xie… - Advanced …, 2024 - Wiley Online Library
In recent years, cancer immunotherapy has undergone a transformative shift toward
personalized and targeted therapeutic strategies. Bacteria‐derived outer membrane …

Components, formulations, deliveries, and combinations of tumor vaccines

T Liu, W Yao, W Sun, Y Yuan, C Liu, X Liu, X Wang… - ACS …, 2024 - ACS Publications
Tumor vaccines, an important part of immunotherapy, prevent cancer or kill existing tumor
cells by activating or restoring the body's own immune system. Currently, various …

Extracellular vesicles from nanomedicine‐trained intestinal microbiota substitute for fecal microbiota transplant in treating ulcerative colitis

M Zu, G Liu, H Xu, Z Zhu, J Zhen, B Li, X Shi… - Advanced …, 2024 - Wiley Online Library
The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical
application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular …

Oral Saccharomyces cerevisiae-Guided Enzyme Prodrug Therapy Combined with Immunotherapy for the Treatment of Orthotopic Colorectal Cancer

YT Qin, X Liu, JX An, Z Chen, MT Niu, X Yan, QR Li… - ACS …, 2024 - ACS Publications
Colorectal cancer (CRC) is a major global health concern, and the development of effective
treatment strategies is crucial. Enzyme prodrug therapy (EPT) shows promise in combating …

Programmed Nanocloak of Commensal Bacteria-Derived Nanovesicles Amplify Strong Immunoreactivity against Tumor Growth and Metastatic Progression

J Zhang, S Wan, H Zhou, J Du, Y Li, H Zhu, L Weng… - ACS …, 2024 - ACS Publications
Recent discoveries in commensal microbiota demonstrate the great promise of intratumoral
bacteria as attractive molecular targets of tumors in improving cancer treatment. However …

Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems

P Gao, Z Duan, G Xu, Q Gong, J Wang… - Advanced …, 2024 - Wiley Online Library
Bacterial‐derived micro‐/nanomedicine has garnered considerable attention in anticancer
therapy, owing to the unique natural features of bacteria, including specific targeting ability …

Lactic acid bacteria derived extracellular vesicles: emerging bioactive nanoparticles in modulating host health

M Li, B Mao, X Tang, Q Zhang, J Zhao, W Chen… - Gut …, 2024 - Taylor & Francis
Lactic acid bacteria derived extracellular vesicles (LAB-EVs) are nano-sized and carry a
variety of biological cargoes. LAB-EVs have proven to be potential mediators of intercellular …

Chronological Management of Adjuvant Effect for Optimized mRNA Vaccine Inspired by Natural Virus Infection

Z Lou, Y Shi, X Guo, Z Jin, J Huang, Y Hu, X Liu… - ACS …, 2024 - ACS Publications
The efficacy and safety of mRNA vaccines both rely on a fine-tuning of specific humoral and
cellular immune responses. Instead of adjustments in vaccine component, we proposed a …

Nano-armor modification of bacteria through supramolecular interactions for disease treatment

X Cao, Y Wang, Q Wang, H Yang, Y Ding… - Coordination Chemistry …, 2024 - Elsevier
Research on nano-armored bacterial materials (NABM) has attracted considerable attention
because of their ability to exert synergistic effects on bacteria and nanomaterials through …

Zinc Oxide‐Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses

W Zhang, Y Lv, Q Niu, C Zhu, H Zhang, K Fan, X Wang - Small, 2024 - Wiley Online Library
Bacterial infection and an excessive inflammatory response are two major factors that affect
the healing of infected wounds. The zinc oxide/copper sulfide (ZnO‐CuS) microspheres …