Mucosa-associated invariant T (MAIT) cells are the largest population of unconventional T
cells in humans. These antimicrobial T cells are poised with rapid effector responses …

Double-membrane-spanning protein complexes, such as the T3SS, had long presented an
intractable challenge for structural biology. As a consequence, until a few years ago, our …

The membrane-embedded injectisome, the structural component of the virulence-associated
type III secretion system (T3SS), is used by Gram-negative bacterial pathogens to inject …

Type III secretion systems are bacterial nanomachines specialized in protein delivery into
target eukaryotic cells. The structural and functional complexity of these machines demands …

Type-3 secretion system injectisomes are multiprotein complexes that translocate bacterial
effector proteins from the cytoplasm of gram-negative bacteria directly into the cytosol of …

One hurdle to understanding how molecular machines work, and how they evolve, is our
inability to see their structures in situ. Here we describe a minicell system that enables in situ …

Shigella is the most common foodborne pathogen and can cause bacillary dysentery.
Therefore, it is necessary to detect Shigella rapidly and accurately, but it is difficult for …

Shigella is a Gram-negative bacterial pathogen that relies on a single type three secretion
system (T3SS) as its primary virulence factor. The T3SS includes a highly conserved needle …

The membrane-embedded injectisome, the structural component of the virulence-associated
type 30 III secretion system (T3SS), is used by gram-negative bacterial pathogens to inject …

The membrane-embedded injectisome, the structural component of the virulence-associated
type III secretion system (T3SS), is used by gram-negative bacterial pathogens to inject …