The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

The well-known Strecker reaction was first documented by the German chemist Adolph
Strecker (1822À1871) in 1850. 1 It was one of the earliest one-pot and atom economic …

Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

Because of their greater stability and unique conformational properties, unnatural amino
acids are highly valued by pharmaceutical, biological, and organic chemists. This synopsis …

Multicomponent reactions (MCRs) have been gaining significance and attention over the
past decade because of their ability to furnish complex products by using readily available …

With the aim of developing new highly porous, heterogeneous Lewis acid catalysts for
multicomponent reactions, a new mesoporous metal–organic framework, InPF-110 ([In3O …

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly
enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem …

A catalytic enantioselective Mukaiyama–Mannich reaction of cyclic C-acylimines with
difluoroenoxysilanes is reported.(S)-TRIP enables the enantioselective synthesis of a series …