Long noncoding RNA functionality in imprinted domain regulation
WA MacDonald, MRW Mann - PLoS genetics, 2020 - journals.plos.org
Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …
Estradiol-induced epigenetically mediated mechanisms and regulation of gene expression
Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene
transcription by binding to estrogen responsive elements in the genome. Besides the …
transcription by binding to estrogen responsive elements in the genome. Besides the …
QSER1 protects DNA methylation valleys from de novo methylation
INTRODUCTION DNA methylation is essential to mammalian development, and
dysregulation can cause serious pathological conditions, including immunodeficiency …
dysregulation can cause serious pathological conditions, including immunodeficiency …
Analysis of transcriptional variability in a large human iPSC library reveals genetic and non-genetic determinants of heterogeneity
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
The Dlk1-Gtl2 locus preserves LT-HSC function by inhibiting the PI3K-mTOR pathway to restrict mitochondrial metabolism
Summary The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …
(ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the …
Imprinted long non-coding RNAs in mammalian development and disease
Imprinted genes play diverse roles in mammalian development, homeostasis, and disease.
Most imprinted chromosomal domains express one or more long non-coding RNAs …
Most imprinted chromosomal domains express one or more long non-coding RNAs …
Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway
L Deng, H Hong, X Zhang, D Chen, Z Chen… - Biochemical and …, 2018 - Elsevier
Our previous long noncoding RNA (lncRNA) microarray results showed that lncRNA MEG3
(maternally expressed 3) was significantly downregulated in human dental follicle cells than …
(maternally expressed 3) was significantly downregulated in human dental follicle cells than …
Transgenerational effects of bisphenol A on gene expression and DNA methylation of imprinted genes in brain
Z Drobná, AD Henriksen, JT Wolstenholme… - …, 2018 - academic.oup.com
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC).
Developmental exposure to BPA changes behavioral and reproductive phenotypes, and …
Developmental exposure to BPA changes behavioral and reproductive phenotypes, and …
[HTML][HTML] EZH2 cooperates with DNA methylation to downregulate key tumor suppressors and IFN gene signatures in melanoma
The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with
DNA methylation and silencing of genes involved in tumor suppression. In this study, we …
DNA methylation and silencing of genes involved in tumor suppression. In this study, we …
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation
Myeloproliferative neoplasms (MPNs) are a group of blood cancers that arise following the
sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells …
sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells …