Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …
evolved unique features distinguishing them from all other protein kinases. The atypical …
Prospects for pharmacological targeting of pseudokinases
Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
Protein kinases are present in all domains of life and play diverse roles in cellular signaling.
Whereas the impact of substrate phosphorylation by protein kinases has long been …
Whereas the impact of substrate phosphorylation by protein kinases has long been …
A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2 …
Z Liu, K Wu, S Gu, W Wang, S Xie, T Lu… - Clinical and …, 2021 - Wiley Online Library
Background Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and
treatment‐resistant tumor. The biological implications and molecular mechanism of cancer …
treatment‐resistant tumor. The biological implications and molecular mechanism of cancer …
Emerging concepts in pseudoenzyme classification, evolution, and signaling
The 21st century is witnessing an explosive surge in our understanding of pseudoenzyme-
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …
Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase
CCAAT-enhancer binding proteins (C/EBPs) are transcription factors that play a central role
in the differentiation of myeloid cells and adipocytes. Tribbles pseudokinases govern levels …
in the differentiation of myeloid cells and adipocytes. Tribbles pseudokinases govern levels …
The evolving world of pseudoenzymes: proteins, prejudice and zombies
Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all
major enzyme families. Their regulatory functions in signalling pathways are shedding new …
major enzyme families. Their regulatory functions in signalling pathways are shedding new …
Pseudokinases: a tribble‐edged sword
L Richmond, K Keeshan - The FEBS Journal, 2020 - Wiley Online Library
Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …
Tracing the origin and evolution of pseudokinases across the tree of life
Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
Pseudokinases: update on their functions and evaluation as new drug targets
The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …
60 signaling proteins, which lacks one or more of the amino acids typically required to …