Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the
central nervous system. After demyelination occurs because of pathophysiology …

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …

Oligodendrocytes (OLs) produce myelin in the central nervous system (CNS), which
accelerates the propagation of action potentials and supports axonal integrity. As a major …

Oligodendrocytes (OLs) produce myelin sheaths around axons in the central nervous
system (CNS). Myelin accelerates the propagation of action potentials along axons and …

SUMO (small ubiquitin like modifier) conjugated proteins have emerged as an important
post translational modifier of cellular function. SUMOylation modulates several cellular …

Mapping enhancers to genes is a fundamental goal of modern biology. We have developed
an innovative strategy that maps enhancers to genes in a principled manner. We illustrate its …

Small ubiquitin like modifiers (SUMO) are reversible posttranslational modifiers of
intracellular proteins. In the CNS, expression of myelin genes is regulated by state of …

Myrf is a membrane-bound transcription factor that plays a key role in various biological
processes. The Intramolecular Chaperone Auto-processing (ICA) domain of Myrf forms a …

Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse
organisms, including in oligodendrocyte differentiation, embryonic development, molting …

Abstract The Myelin Regulator Factor (MYRF) is a master regulator governing myelin
formation and maintenance in the central nervous system. The conservation of MYRF across …