The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost …

Understanding immune responses after severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) breakthrough infection will facilitate the development of next-generation …

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …

The recently discovered SARS-CoV-2 variant Omicron (B. 1.1. 529) has rapidly become a
global public health issue. The substantial mutations in the spike protein in this new variant …

B cells play a fundamental role in host defenses against viral infections. Profiling the B cell
response elicited by SARS-CoV-2 vaccination, including the generation and persistence of …

Immunological imprinting by ancestral SARS-CoV-2 strains is thought to impede the robust
induction of Omicron-specific humoral responses by Omicron-based booster vaccines. Here …

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening
COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination …

How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …

Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure
levels of antibodies to the receptor-binding domain of ancestral SARS-CoV-2 (RBDwt) …

Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-
2 infection and transmission, but both reduce the risk of severe COVID-19. To generate …