Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions
SH Francis, MA Blount, JD Corbin - Physiological reviews, 2011 - journals.physiology.org
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
M Conti, J Beavo - Annu. Rev. Biochem., 2007 - annualreviews.org
Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives …
T Keravis, C Lugnier - British journal of pharmacology, 2012 - Wiley Online Library
Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …
messengers cAMP and cGMP in a compartmentalized manner represent an important …
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
Keynote review: phosphodiesterase-4 as a therapeutic target
MD Houslay, P Schafer, KYJ Zhang - Drug discovery today, 2005 - Elsevier
Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …
Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges
Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …
intensive care unit and, despite advances in overall medical care, it represents a major …
Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A-and phosphatidylinositol 3-kinase/Akt-dependent mechanism
A Hashimoto, G Miyakoda, Y Hirose, T Mori - Atherosclerosis, 2006 - Elsevier
We investigated the effect of cilostazol on nitric oxide (NO) production in human aortic
endothelial cells (HAEC). Cilostazol increased NO production in a concentration-dependent …
endothelial cells (HAEC). Cilostazol increased NO production in a concentration-dependent …
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
R Rajkumar, K Konishi, TJ Richards… - American Journal …, 2010 - journals.physiology.org
Idiopathic pulmonary arterial hypertension (PAH) is a life-threatening condition
characterized by pulmonary arteriolar remodeling. This investigation aimed to identify genes …
characterized by pulmonary arteriolar remodeling. This investigation aimed to identify genes …
Targeting cancer with phosphodiesterase inhibitors
R Savai, SS Pullamsetti, GA Banat… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: For many cancers, there has been a shift from management with
traditional, nonspecific cytotoxic chemotherapies to treatment with molecule-specific …
traditional, nonspecific cytotoxic chemotherapies to treatment with molecule-specific …
Pulmonary vascular changes in asthma and COPD
LM Harkness, V Kanabar, HS Sharma… - Pulmonary …, 2014 - Elsevier
In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease
(COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels …
(COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels …