From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

3D human induced pluripotent stem cell–derived bioengineered skeletal muscles for tissue, disease and therapy modeling

L Pinton, M Khedr, VM Lionello, S Sarcar… - Nature …, 2023 - nature.com
Skeletal muscle is a complex tissue composed of multinucleated myofibers responsible for
force generation that are supported by multiple cell types. Many severe and lethal disorders …

Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function

JH Kim, I Kim, YJ Seol, IK Ko, JJ Yoo, A Atala… - Nature …, 2020 - nature.com
A bioengineered skeletal muscle construct that mimics structural and functional
characteristics of native skeletal muscle is a promising therapeutic option to treat extensive …

Bioprinted anisotropic scaffolds with fast stress relaxation bioink for engineering 3D skeletal muscle and repairing volumetric muscle loss

T Li, J Hou, L Wang, G Zeng, Z Wang, L Yu, Q Yang… - Acta Biomaterialia, 2023 - Elsevier
Viscoelastic hydrogels can enhance 3D cell migration and proliferation due to the faster
stress relaxation promoting the arrangement of the cellular microenvironment. However …

Chemical modification of human decellularized extracellular matrix for incorporation into phototunable hybrid-hydrogel models of tissue fibrosis

RS Hewawasam, R Blomberg… - … applied materials & …, 2023 - ACS Publications
Tissue fibrosis remains a serious health condition with high morbidity and mortality rates.
There is a critical need to engineer model systems that better recapitulate the spatial and …

Prevascularized micro-/nano-sized spheroid/bead aggregates for vascular tissue engineering

M Rahimnejad, N Nasrollahi Boroujeni, S Jahangiri… - Nano-Micro Letters, 2021 - Springer
Efficient strategies to promote microvascularization in vascular tissue engineering, a central
priority in regenerative medicine, are still scarce; nano-and micro-sized aggregates and …

Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond

S Jalal, S Dastidar, FS Tedesco - Current opinion in cell biology, 2021 - Elsevier
Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model
complex developmental dynamics and disease mechanisms not recapitulated in animal …

Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies

SW Choi, G Ferrari, FS Tedesco - EMBO molecular medicine, 2020 - embopress.org
Directional cell migration is a critical process underlying morphogenesis and post‐natal
tissue regeneration. During embryonic myogenesis, migration of skeletal myogenic …

Contractile force assessment methods for in vitro skeletal muscle tissues

C Vesga-Castro, J Aldazabal, A Vallejo-Illarramendi… - Elife, 2022 - elifesciences.org
Over the last few years, there has been growing interest in measuring the contractile force
(CF) of engineered muscle tissues to evaluate their functionality. However, there are still no …

The impact of immune cells on the skeletal muscle microenvironment during cancer cachexia

BN VanderVeen, EA Murphy, JA Carson - Frontiers in Physiology, 2020 - frontiersin.org
Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a
common comorbidity associated with cancer that results in adverse consequences for the …