Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity
TA Farghaly, GS Masaret, ZA Muhammad… - Bioorganic chemistry, 2020 - Elsevier
The crucial need for novel antitumor agents with high selectivity toward cancer cells has
promoted us to synthesize new series of thiazole-based chalcones and 4-hetarylthiazoles …
promoted us to synthesize new series of thiazole-based chalcones and 4-hetarylthiazoles …
Novel 1, 3-thiazole analogues with potent activity against breast cancer: A design, synthesis, in vitro, and in silico study
MG Salem, DMA El-Maaty, YIM El-Deen, BH Elesawy… - Molecules, 2022 - mdpi.com
Breast cancer is the most common cancer in women, responsible for over half a million
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …
Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery
SR Alizadeh, SM Hashemi - Medicinal Chemistry Research, 2021 - Springer
Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
Design, synthesis and biological evaluation of novel 5, 6, 7-trimethoxy-N-aryl-2-styrylquinolin-4-amines as potential anticancer agents and tubulin polymerization …
A new series of styrylquinolines was designed and synthesized as anticancer agents and
tubulin polymerization inhibitors. The in vitro anticancer activity of the synthesized quinolines …
tubulin polymerization inhibitors. The in vitro anticancer activity of the synthesized quinolines …
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
Y Wan, J Long, H Gao, Z Tang - European Journal of Medicinal Chemistry, 2021 - Elsevier
Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …
human society. Although many efforts have been taken for cancer therapy and many …
Synthesis, molecular docking and antiproliferative activity studies of a thiazole‐based compound linked to hydrazone moiety
Abstract (A new 4‐oxothiazolidin‐2‐ylidene derivative bearing hydrazone moiety was
synthesized via Michael addition between the reaction of 4‐(4‐nitrophenyl)‐3 …
synthesized via Michael addition between the reaction of 4‐(4‐nitrophenyl)‐3 …
[HTML][HTML] Coumarin-heterocycle framework: A privileged approach in promising anticancer drug design
A Dorababu - European Journal of Medicinal Chemistry Reports, 2021 - Elsevier
The cancer cases are increasing in fast pace; most of them are resulted from exposure to
harmful pollutants. Genetic factors are responsible for cancer only to a small extent …
harmful pollutants. Genetic factors are responsible for cancer only to a small extent …
[HTML][HTML] Synthesis of new thiazole-privileged chalcones as tubulin polymerization inhibitors with potential anticancer activities
A series of novel thiazole-based chalcones were evaluated for their anticancer activity as
potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole …
potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole …