Targeted drug delivery strategies for precision medicines

MT Manzari, Y Shamay, H Kiguchi, N Rosen… - Nature Reviews …, 2021 - nature.com
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Designing smart polymer conjugates for controlled release of payloads

F Seidi, R Jenjob, D Crespy - Chemical reviews, 2018 - ACS Publications
Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

Multifunctional dendritic polymers in nanomedicine: opportunities and challenges

J Khandare, M Calderón, NM Dagia… - Chemical Society …, 2012 - pubs.rsc.org
Nanotechnology has resulted in materials that have greatly improved the effectiveness of
drug delivery because of their ability to control matter on the nanoscale. Advanced forms of …

Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

X Deng, J Wang, S Yu, S Tan, T Yu, Q Xu, N Chen… - …, 2024 - Wiley Online Library
Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to
human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency …

Polymer nanomedicines

J Kopeček, J Yang - Advanced drug delivery reviews, 2020 - Elsevier
Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

Signaling mechanism of cell adhesion molecules in breast cancer metastasis: potential therapeutic targets

DM Li, YM Feng - Breast cancer research and treatment, 2011 - Springer
Metastasis is responsible for the majority of breast cancer-related deaths. The metastatic
spread of cancer cells is a complicated process that requires considerable flexibility in the …

Peptide ligand-modified nanomedicines for targeting cells at the tumor microenvironment

A David - Advanced drug delivery reviews, 2017 - Elsevier
Since their initial discovery more than 30 years ago, tumor-homing peptides have become
an increasingly useful tool for targeted delivery of therapeutic and diagnostic agents into …

Peptide‐mediated targeted drug delivery

S Majumdar, TJ Siahaan - Medicinal research reviews, 2012 - Wiley Online Library
Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the
undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear …

E-selectin as a target for drug delivery and molecular imaging

E Jubeli, L Moine, J Vergnaud-Gauduchon… - Journal of controlled …, 2012 - Elsevier
E-selectin, also known as CD62E, is a cell adhesion molecule expressed on endothelial
cells activated by cytokines. Like other selectins, it plays an important part in inflammation …

Biodegradable block copolymer-doxorubicin conjugates via different linkages: preparation, characterization, and in vitro evaluation

X Hu, S Liu, Y Huang, X Chen, X Jing - Biomacromolecules, 2010 - ACS Publications
Doxorubicin (Dox) was conjugated onto a biodegradable block copolymer methoxy-poly
(ethylene glycol)-block-poly (lactide-co-2, 2-dihydroxymethylpropylene carbonate (mPEG …