The generation of the components that make up the embryonic body axis, such as the spinal
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

Oscillatory and sequential processes have been implicated in the spatial patterning of many
embryonic tissues. For example, molecular clocks delimit segmental boundaries in …

Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-
posterior body axis establishment and subsequent spinal cord development, but these …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …

The complex neuromuscular network that controls body movements is the target of severe
diseases that result in paralysis and death. Here, we report the development of a robust and …

The chromosomally-arrayed Hox gene family plays central roles in embryonic patterning
and the specification of cell identities throughout the animal kingdom. In vertebrates, the …

Animal body plans are established during embryonic development by the Hox genes. This
patterning process relies on the differential expression of Hox genes along the head-to-tail …

Stem cells display a unique cell type within the body that has the capacity to self-renew and
differentiate into specialized cell types. Compared to pluripotent stem cells, adult stem cells …

Inflammation is a shared hallmark between amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). For long, studies were conducted on tissues of post-mortem …