Vision is the most important sense for humans and it is irreversibly impaired by axonal
damage of retinal ganglion cells (RGCs) in the optic nerve due to the lack of axonal …

Myopia affected approximately 1.6 billion people worldwide in 2000, and it is expected to
increase to 2.5 billion by 2020. Although optical problems can be corrected by optics or …

Abstract Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a
loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The …

Background & Aims The tumour microenvironment shapes tumour growth through cellular
communications that include both direct interactions and secreted factors. The aim of this …

A preferential loss of retinal ganglion cells (RGCs) is observed in glaucoma and optic
neuritis. Loss of tropomyosin-related kinase receptor B (TrkB)-mediated signaling has been …

Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET
are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes …

Mesial temporal lobe epilepsy (mTLE) is a chronic and often treatment-refractory brain
disorder characterized by recurrent seizures originating from the hippocampus. The …

Extracellular matrix (ECM) integrity in the central nervous system (CNS) is essential for
neuronal homeostasis. Signals from the ECM are transmitted to neurons through integrins, a …

Axonal regeneration is an essential condition to re-establish functional neuronal
connections in the injured adult central nervous system (CNS), but efficient regrowth of …

Glaucoma, the second leading cause of blindness worldwide, is an incurable
neurodegenerative disorder due to the dysfunction of retinal ganglion cells (RGCs). RGCs …