Gankyrin is found in high levels in triple-negative breast cancer (TNBC) and has been
established to form a complex with the E3 ubiquitin ligase MDM2 and p53, resulting in the …

The majority of novel targeted anticancer drugs are weakly basic molecules with poor
aqueous solubility which ultimately compromise their oral bioavailability. Lenvatinib (Lnv) is …

Liver cancer is a complex disease that involves various oncoproteins and the inactivation of
tumor suppressor proteins (TSPs). Gankyrin is one such oncoprotein, first identified in …

Background: Gankyrin is an ankyrin-repeat protein that promotes cell proliferation, tumor
development and cancer progression when overexpressed. Aim: To design and synthesize …

Gankyrin has a household function in essentially all cells by acting as a chaperone in the
assembly of the 26S proteasome, but also functions as a tumor-promoting protein by …

Аннотация Азотсодержащие гетероциклические соединения-триазолы являются
важным селективным классом производных в химиотерапии против линий опухолевых …

Gankyrin is a seven ankyrin repeat containing oncoprotein overexpressed in numerous
cancer types such as lung, breast, prostate, colorectal, and many more. Gankyrin binds to S6 …

The essential pathways that regulate neurodevelopmental processes involve a myriad of
post-translational modifications (PTMs) such as ubiquitylation that systematically control …