Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-
renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …

Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

Metabolomics holds the promise as a new technology to diagnose highly heterogeneous
diseases. Conventionally, metabolomics data analysis for diagnosis is done using various …

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are
highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for …

A plethora of treatment options exist for cancer therapeutics, but many are limited by side
effects and either intrinsic or acquired resistance. The need for more effective targeted …